Influence of a Nonionic, Iso-Osmolar Contrast Medium (Iodixanol) Versus an Ionic, Low-Osmolar Contrast Medium (Ioxaglate) on Major Adverse Cardiac Events in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty

Iso-Osmolar versus Low-Osmolar Contrast Media in Reducing Contrast Induced Nephropathy in Patient with Renal Impairment Undergoing Coronary Angiography

Renal failure in 57 925 patients undergoing coronary procedures using iso-osmolar or low-osmolar contrast media.

We compared the Swedish Coronary Angiography and Angioplasty Registry with the Swedish 'Hospital Discharge Register' to assess contrast media (CM)-induced renal failure. Hospitals used only one type CM. From 2000 to 2003, iodixanol (iso-osmolar) was used in 45 485 patients, ioxaglate (low osmolar) in 12 440 subjects. To include the earlier used CM iohexol (low osmolar), analysis extended back t...

Comparison of ionic, monomer, high osmolar contrast media with non-ionic, dimer, iso-osmolar contrast media in ERCP.

OBJECTIVE Pancreatitis is the most common and serious complication of endoscopic retrograde cholangiopancreatography (ERCP). Several studies have compared contrast media (CM) with different osmolalities, but the results are conflicting. We conducted this study to clarify the difference between 2 CM used in ERCP. METHODS Five hundred and seventy-six patients were examined by using ERCP in our ...

Interventional Cardiology A Randomized Trial Comparing the Impact of a Nonionic (Iomeprol) Versus an Ionic (Ioxaglate) Low Osmolar Contrast Medium on Abrupt Vessel Closure and Ischemic Complications After Coronary Angioplasty

METHODS We prospectively evaluated the outcomes of 2,000 patients undergoing percutaneous transluminal coronary angioplasty (PTCA). According to a randomized, double-blind protocol, they received either iomeprol (nonionic; n 5 1,001) or ioxaglate (ionic; n 5 999). Intracoronary thrombus before PTCA was found more often in the iomeprol group (4.2% vs 2.7%, p 5 0.04). No other significant differe...

Contrast media induced nephropathy: CONTRAST There is an ongoing controversy on the impact of iso- osmolar contrast agents on contrast media induced nephropathy (CIN). The COntrast Media and Neph- roToxicity Following Coronary Revascularization by AngioplaSTy

There is an ongoing controversy on the impact of isoosmolar contrast agents on contrast media induced nephropathy (CIN). The COntrast Media and NephroToxicity Following Coronary Revascularization by AngioplaSTy (CONTRAST) randomized 324 patients with impaired renal function undergoing PCI to receive either the iso-osmolar contrast medium iodixanol 320 (Visipaque ) or the low-osmolar contrast me...